Induction of Cataract-like Changes in Rat Lens Epithelial Explants by Transforming Growth Factor /?
نویسندگان
چکیده
Results. TGFjj induced cells in explants to undergo an extensive and rapid elongation with features that distinguished ii from FGF-induced fiber differentiation. TGF^also induced accumulation of extracellular matrix, capsule wrinkling, cell death by apoptosis, and distinctive arrangements of cells. Standard explains from J 0-day-old rats responded to TGF^ only in the presence of FGF. Comparable explants from adult rats or from 2 1-day-old rats (cultured on a laminin substratum) responded readily to TGF^ whether or not FGF was present.
منابع مشابه
Induction of cataract-like changes in rat lens epithelial explants by transforming growth factor beta.
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تاریخ انتشار 2005